Cerebral primitive neuro-ectodermal tumour following treatment of a unilateral retinoblastoma.

Abstract

Cerebral primitive neuro-ectodermal tumour (PNET) occurring as a second primary malignancy in childhood is exceedingly rare. We present a 7-year-old boy who developed a proven supratentorial PNET five years after enucleation and radio-/chemotherapy for a sporadic, unilateral retinoblastoma with optic nerve invasion. The association with this malignant eye disease as well as the effect of irradiation and multi-agent chemotherapy on second tumour induction are evaluated.

• Authors: G Dorfmüller, F G Würtz, R Kleinert, G Lanner
• Journal: Acta neurochirurgica (Acta Neurochir (Wien)) Vol. 139 Issue 8 Pg. 749-55 ( 1997) ISSN: 0001-6268 [Print] Austria
• PMID: 9309290 (Publication Type: Case Reports, Journal Article)

Topics

• Chemotherapy, Adjuvant
• Child
• Combined Modality Therapy
• Eye Enucleation
• Humans
• Magnetic Resonance Imaging
• Male
• Neoplasm Invasiveness
• Neoplasms, Second Primary (diagnosis, genetics)
• Neuroectodermal Tumors, Primitive (diagnosis, genetics)
• Optic Nerve (pathology)
• Postoperative Complications (diagnosis)
• Radiotherapy, Adjuvant
• Retinal Neoplasms (genetics, therapy)
• Retinoblastoma (genetics, therapy)
• Risk Factors
• Supratentorial Neoplasms (diagnosis, genetics)