Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis.

Abstract

OBJECTIVE:

To explore in a cross sectional study in patients with primary knee osteoarthritis (OA) the relations between body mass index (BMI), disease stage, and the concentrations of a putative joint fluid marker of type II collagen synthesis, procollagen II C-propeptide.

PATIENTS AND METHODS:

The study included 142 patients with knee OA (median age 68, median BMI 24.1). OA was staged radiologically. The concentrations in synovial fluid of procollagen II C-propeptide were measured by a sandwich enzyme immunoassay.

RESULTS:

Joint fluid concentrations of procollagen II C-propeptide were increased in knees with OA (median 3.7 ng/ml), compared with published reference values for knees in healthy adult volunteers (median 1.3 ng/ml). The concentrations of procollagen II C-propeptide were independently related to both OA stage and BMI (r = 0.343, p < 0.0001 and r, = 0.253, p = 0.002, respectively).

CONCLUSIONS:

Joint fluid concentrations of this putative marker of collagen II synthesis are high in early and mid-stage OA, but decrease in end stage disease. In addition and for the first time it was shown that the concentrations in synovial fluid of procollagen II C-propeptide increase with increasing BMI in primary knee OA. The increased joint fluid values of this marker in patients with primary knee OA and a high BMI, may reflect increased rates of collagen synthesis in their joint cartilage and could relate to the previously shown increased risk for disease progression in such patients.

• Authors: T Kobayashi, Y Yoshihara, A Samura, H Yamada, M Shinmei, H Roos, L S Lohmander
• Journal: Annals of the rheumatic diseases (Ann Rheum Dis) Vol. 56 Issue 8 Pg. 500-3 (Aug 1997) ISSN: 0003-4967 [Print] England
• PMID: 9306875 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Calcium-Binding Proteins
• Collagen Type II
• Protein Precursors
• chondrocalcin
• Collagen

Topics

• Adult
• Aged
• Aged, 80 and over
• Analysis of Variance
• Biomarkers (analysis)
• Body Mass Index
• Calcium-Binding Proteins (analysis)
• Collagen (analysis)
• Collagen Type II
• Cross-Sectional Studies
• Disease Progression
• Female
• Humans
• Immunoenzyme Techniques
• Knee Joint (diagnostic imaging)
• Male
• Middle Aged
• Osteoarthritis (diagnostic imaging, metabolism)
• Protein Precursors (analysis)
• Radiography
• Regression Analysis
• Risk Factors
• Synovial Fluid (chemistry)