Neokyotorphin and neokyotorphin (1-4): secretion by erythrocytes and regulation of tumor cell growth.

Abstract

Human erythrocytes release neokyotorphin, the 137-141 fragment of hemoglobin alpha-chain into the supernatant of red blood cells primary culture. However, the neokyotorphin fragment 1-4 that is formed together with neokyotorphin inside the red blood cells and in various tissues is not found in the supernatant. Both neokyotorphin and its 1-4 fragment were shown to stimulate proliferation of L929 tumor cells.

• Authors: E Y Blishchenko, O A Mernenko, O N Yatskin, R H Ziganshin, M M Philippova, A A Karelin, V T Ivanov
• Journal: FEBS letters (FEBS Lett) Vol. 414 Issue 1 Pg. 125-8 (Sep 01 1997) ISSN: 0014-5793 [Print] England
• PMID: 9305745 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Endorphins
• Peptide Fragments
• neokyotorphin (1-4)
• neo-kyotorphin

Topics

• Cell Division (drug effects)
• Chromatography, High Pressure Liquid
• Endorphins (metabolism, pharmacology)
• Erythrocytes (metabolism)
• Humans
• Peptide Fragments (metabolism, pharmacology)
• Sequence Analysis
• Tumor Cells, Cultured