Quantitative aspects of transplantation of experimentally induced tumors of the nervous system.

Abstract

Quantitative aspects of transplantation have been studied experimentally in ethylnitrosourea-induced nervous system tumors. The number of cells needed for successful transplantation, the biological behaviour-increase of malignancy-of the tumor in relation to the number of cells used during the various passages, and the relationship between number of grafted cells and induction time have been examined. A "critical" number of cells was necessary to ensure a positive result; thereafter, the induction time was directly related to the logarithm of the number of cells implanted.

• Authors: H D Mennel, P Groneck
• Journal: Acta neuropathologica (Acta Neuropathol) Vol. 40 Issue 2 Pg. 145-50 (Oct 10 1977) ISSN: 0001-6322 [Print] Germany
• PMID: 930562 (Publication Type: Journal Article)

Chemical References

• Ethylnitrosourea

Topics

• Animals
• Cell Count
• Ethylnitrosourea
• Glioma (pathology)
• Neoplasm Transplantation
• Neoplasms, Experimental (chemically induced, pathology)
• Nervous System Diseases (chemically induced, pathology)
• Rats
• Time Factors
• Transplantation, Homologous