Haemodynamic effects of hypotension induced by KRN2391 and nicardipine in isoflurane anaesthetized dogs.

Abstract

PURPOSE:

The investigational agent, KRN2391, is a potassium channel opener with a nitrate moiety which possesses potent vasodilatory action. We compared the haemodynamic effect of KRN2391. Induced hypotension with those of nicardipine.

METHODS:

Sixteen dogs were anaesthetized with isoflurane 1.3% in oxygen (1 MAC). After the baseline period. mean arterial pressure (MAP) was decreased to 60 mmHg for 60 min with an infusion nicardipine (n = 8).

RESULTS:

The KRN2391- and nicardipine-induced hypotension resulted in maximal decreased systemic vascular resistance of 35% and 25%, increases in cardiac index of 145% and 197%, and stroke volume index of 150% and 212%, respectively, (P < 0.01). There was no change in heart rate. Nicardipine was associated with increases (P < 0.01) in both right atrial and mean pulmonary artery pressures, whereas these variables remained unchanged with KRN2391. Pulmonary capillary wedge pressure decreased with KRN2391 (P < 0.01), but not with nicardipine.

CONCLUSION:

While both drugs were equally able of inducing hypotension, our results show that the haemodynamic profile of KRN2391- and nicardipine-induced hypotension was a hyperdynamic state expressed by the marked increase in cardiac index with varying changes in right and left ventricular filling pressures, and suggest that KRN2391 may be a useful vasodilator for induced hypotension.

• Authors: S Takeda, Y Ozawa, T Tomaru
• Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie (Can J Anaesth) Vol. 44 Issue 9 Pg. 1002-7 (Sep 1997) ISSN: 0832-610X [Print] United States
• PMID: 9305565 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anesthetics, Inhalation
• Antihypertensive Agents
• Calcium Channel Blockers
• Potassium Channels
• Pyridines
• Vasodilator Agents
• N-cyano-N'-(2-nitroxyethyl)-3-pyridinecarboximidamide methanesulfonate
• Isoflurane
• Nicardipine

Topics

• Anesthesia, Inhalation
• Anesthetics, Inhalation (administration & dosage)
• Animals
• Antihypertensive Agents (administration & dosage, pharmacology)
• Atrial Function, Right (drug effects)
• Blood Pressure (drug effects)
• Calcium Channel Blockers (administration & dosage, pharmacology)
• Cardiac Output (drug effects)
• Dogs
• Female
• Heart Rate (drug effects)
• Hemodynamics (drug effects)
• Hypotension, Controlled
• Infusions, Intravenous
• Isoflurane (administration & dosage)
• Male
• Nicardipine (administration & dosage, pharmacology)
• Potassium Channels (drug effects)
• Pulmonary Artery (drug effects)
• Pulmonary Wedge Pressure (drug effects)
• Pyridines (administration & dosage, pharmacology)
• Stroke Volume (drug effects)
• Vascular Resistance (drug effects)
• Vasodilator Agents (administration & dosage, pharmacology)
• Ventricular Function, Left (drug effects)
• Ventricular Function, Right (drug effects)
• Ventricular Pressure (drug effects)