Haemodynamic effects of chronic tetrandrine treatment in portal hypertensive rats.

Abstract

Tetrandrine is a calcium channel antagonist with reported antihypertensive effect. However, the potential role of tetrandrine as a therapeutic agent in portal hypertension has yet to be explored. The present study aimed to investigate the haemodynamic effects of chronic tetrandrine treatment on portal hypertensive rats. Portal hypertension was induced by partial portal vein ligation in Sprague-Dawley rats. Animals were allocated into one of two groups: a tetrandrine group and a vehicle group. Tetrandrine (20 mg/kg) or vehicle was administered by gavage every 12 h for 8 consecutive days, starting 1 day before ligation and continuing thereafter. After 8 days of tetrandrine treatment, systemic haemodynamics, organ blood flow and the degree of portal-systemic shunting were measured after an overnight fast. The portal venous pressure and protal tributary blood flow were significantly decreased, while portal territory as well as hepto-collateral vascular resistance significantly increased in the tetrandrine group compared with the vehicle group. The cardiac index was increased, while systemic vascular resistance was decreased, the the tetrandrine group. Mean arterial pressure, heart rate, portal-systemic shunting and bodyweight were similar between the two groups. Renal blood flow was decreased in the tetrandrine group. In conclusion, long-term treatment of tetrandrine reduced portal venous pressure and alleviated splanchnic hyperaemina in portal hypertensive rats without affecting the portal-systemic shunting.

• Authors: Y T Huang, Y R Cheng, H C Lin, C F Chen, C Y Hong
• Journal: Journal of gastroenterology and hepatology (J Gastroenterol Hepatol) Vol. 12 Issue 8 Pg. 585-9 (Aug 1997) ISSN: 0815-9319 [Print] Australia
• PMID: 9304511 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Antihypertensive Agents
• Benzylisoquinolines
• Calcium Channel Blockers
• tetrandrine

Topics

• Alkaloids (therapeutic use)
• Animals
• Antihypertensive Agents (therapeutic use)
• Benzylisoquinolines
• Calcium Channel Blockers (therapeutic use)
• Hemodynamics (drug effects)
• Hypertension, Portal (drug therapy, physiopathology)
• Male
• Portal Pressure (drug effects)
• Rats
• Rats, Sprague-Dawley
• Splanchnic Circulation (drug effects)