Raccoon poxvirus live recombinant feline panleukopenia virus VP2 and rabies virus glycoprotein bivalent vaccine.

A raccoon poxvirus (RCNV) recombinant for immunizing against feline panleukopenia and rabies was developed by homologous recombination with a chimeric plasmid for insertional inactivation of the RCNV thymidine kinase gene. The recombinant, RCN-FPV/VP2-rabG, coexpressed the feline panleukopenia virus (FPV) VP2 protein and the rabies virus spike glycoprotein (rabG) under oppositely oriented vaccinia virus P11 promoters. Cats vaccinated subcutaneously with the recombinant showed relatively high neutralizing antibody responses against rabies virus and FPV, and protection against an otherwise virulent FPV challenge with no drop in white blood cell count. Because of containment constraints, no rabies virus challenges were done, but the high concentrations (> 8 IU) of rabies neutralizing antibodies were consistent with levels that usually indicate an ability to counter the infection.
AuthorsL Hu, C Ngichabe, C V Trimarchi, J J Esposito, F W Scott
JournalVaccine (Vaccine) 1997 Aug-Sep Vol. 15 Issue 12-13 Pg. 1466-72 ISSN: 0264-410X [Print] ENGLAND
PMID9302762 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Viral
  • Antigens, Viral
  • Glycoproteins
  • Rabies Vaccines
  • Vaccines, Synthetic
  • Viral Envelope Proteins
  • Viral Structural Proteins
  • Viral Vaccines
  • glycoprotein G, Rabies virus
  • Animals
  • Antibodies, Viral (blood)
  • Antigens, Viral
  • Cats
  • Feline Panleukopenia Virus (immunology)
  • Glycoproteins (immunology)
  • Orthopoxvirus (genetics)
  • Rabies Vaccines (immunology)
  • Raccoons
  • Vaccines, Synthetic (immunology)
  • Viral Envelope Proteins (immunology)
  • Viral Structural Proteins (immunology)
  • Viral Vaccines (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: