Abstract | BACKGROUND: METHODS: Rats with experimentally induced gastric ulcers were treated twice daily for 14 days either with sulglycotide at 200 mg/kg or vehicle, and at different stages of the treatment their stomachs were used for macroscopic damage assessment and quantitation of gastric mucosal Cdk2 and PCNA expression. RESULTS: The assays showed that the ulcer healing was accompanied by an increase in mucosal expression of Cdk2 and PCNA. The maximum increase in Cdk2 (2.3-fold) occurred by the 4th day of healing. An accelerated ulcer healing (10 days) with sulglycotide treatment was reflected in a marked enhancement in Cdk2 expression attained a maximum 2.1-fold increase by the 6th day of treatment and remained substantially increased for up to 10 days. CONCLUSIONS: The findings show a complex interplay between the extracellular cues and cell cycle regulatory proteins, an orderly progression that drives the mucosal repair process. We also show that the gastroprotective agent sulglycotide is capable of affecting the expression of the cell cycle regulatory proteins that control cell cycle progression through G1 and into S phase.
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Authors | B L Slomiany, J Piotrowski, A Slomiany |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 32
Issue 9
Pg. 873-7
(Sep 1997)
ISSN: 0036-5521 [Print] England |
PMID | 9299663
(Publication Type: Journal Article)
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Chemical References |
- Anti-Ulcer Agents
- Proliferating Cell Nuclear Antigen
- Sialoglycoproteins
- sulglicotide
- Cyclin-Dependent Kinases
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Topics |
- Animals
- Anti-Ulcer Agents
(therapeutic use)
- Cell Cycle
- Cyclin-Dependent Kinases
(metabolism)
- Enzyme-Linked Immunosorbent Assay
- Gastric Mucosa
(drug effects, metabolism, pathology)
- Proliferating Cell Nuclear Antigen
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Sialoglycoproteins
(therapeutic use)
- Stomach Ulcer
(drug therapy, pathology)
- Wound Healing
(drug effects)
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