Abstract | OBJECTIVE: The aims of this work were to describe the therapeutic options available for severe hyperammonemia in children when ammonium levels are so high that the child's neurologic future or even their life is compromised. In addition, a comparison of the relative efficacy of each therapeutic method is made. PATIENTS AND METHODS: RESULTS:
Peritoneal dialysis was the method that obtained the greatest reduction in plasma ammonium levels. However, the quickest reduction was observed with ET and HD. There were no significant complications with any of the methods except for hemodynamic deterioration in one patient during HD. CONCLUSIONS: We believe that HD is the treatment of choice for these patients because it is able to obtain a quick and lasting clearance of plasma ammonium. However, this method is not always available and has not been used very often in small babies. In these cases, the combined use of ET and DP can be very useful.
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Authors | M J Pérez Rodríguez, J L Vázquez Martínez, M Martínez-Pardo Casanova, I Martos Sánchez, C Lozano Jiménez, N Gallego Cobos |
Journal | Anales espanoles de pediatria
(An Esp Pediatr)
Vol. 46
Issue 5
Pg. 460-3
(May 1997)
ISSN: 0302-4342 [Print] Spain |
Vernacular Title | Eficacia de las diversas medidas terapéuticas en la hiperamoniemia de origen metabólico. |
PMID | 9297399
(Publication Type: Case Reports, Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)
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Chemical References |
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Topics |
- Ammonia
(metabolism)
- Child
- Child, Preschool
- Exchange Transfusion, Whole Blood
- Female
- Humans
- Infant, Newborn
- Metabolism, Inborn Errors
(therapy)
- Peritoneal Dialysis
- Renal Dialysis
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