[Relationship between the level of specific antibodies with disease outcome in Cercopithecus aethiops monkeys in experimental Marburg disease].

Abstract

The level of specific antibodies in the blood of Cercopithecus aethiops monkeys with experimental Marburg hemorrhagic fever appreciably affects the incidence of lethal outcomes in immunized animals infected with Marburg virus. This effect manifests starting from the titers as low as just 1:100. The level of humoral immunity with the specific antibody titer of at least 1:100 depends on the method of antigen preparation. Humoral response was higher upon challenge with formalin-inactivated virus isolated from the blood plasma of infected guinea pigs.

• Authors: O A Agafonova, S A Viazunov, V A Zhukov, N A Krivenchuk, S A Krotov, N I Nikolenko, A Iu Tereshchenko, V G Frolov, A M Shestopalov, N B Bazhutin
• Journal: Voprosy virusologii (Vopr Virusol) 1997 May-Jun Vol. 42 Issue 3 Pg. 109-11 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: O vzaimosviazi urovnia spetsificheskikh antitel s iskhodom zabolevaniiau obez'ian Cerpithecus aethiops pri éksperimental'noĭ infektsii virus Marburg.
• PMID: 9297338 (Publication Type: Journal Article)

Chemical References

• Antibodies, Viral
• Viral Vaccines

Topics

• Animals
• Antibodies, Viral (blood)
• Chlorocebus aethiops
• Guinea Pigs
• Marburg Virus Disease (immunology)
• Serial Passage
• Viral Vaccines