[Sandimmun in the treatment of chronic glomerulonephritis with the nephrotic syndrome]

• Abstract: Sandimmun was given to 11 patients (7 males and 4 females) aged 16-34 years with chronic glomerulonephritis (CGN) and nephrotic syndrome (NS). Various morphological forms were revealed: minimal changes (MC), focal-segmentary glomerulosclerosis (FSGS), mesangiocapillary glomerulonephritis (MCGS), membraneous glomerulonephritis (MGN), mesangioproliferative glomerulonephritis (MPGN). They occurred in 1, 3, 2, 1 and 3 patients respectively. Biopsy was not made in 1 case. The duration of the disease varied from 1 to 4 years. Prior to this therapy 10 patients failed corticosteroids and cytostatics. Hypertension, high creatinine were registered in 3 and 5 patients, respectively. Sandimmun was given for 2-18 months in a daily dose 3-5 mg/kg. Serum concentration 70-180 ng/ml. After 1 to 18 months of treatment nephrotic syndrome relieved in 1 MGN, 3 MPGN, 2 FSGS, 2 MCGS patients. The recurrences were reported in 4 patients after the drug discontinuation. Serious complications were absent.
• Authors: T N Krasnova, I E Tareeva, E M Shilov, N A Mukhin, N G Miroshnichenko
• Journal: Terapevticheskiĭ arkhiv (Ter Arkh) Vol. 69 Issue 6 Pg. 21-3 ( 1997) ISSN: 0040-3660 [Print] RUSSIA
• Vernacular Title: Sandimmun v lechenii khronicheskogo glomerulonefrita s nefroticheskim sindromom.
• PMID: 9297266 (Publication Type: English Abstract, Journal Article)

Chemical References

• Immunosuppressive Agents
• Cyclosporine

Topics

• Adolescent
• Adult
• Chronic Disease
• Cyclosporine (adverse effects, therapeutic use)
• Drug Evaluation
• Female
• Glomerulonephritis (complications, drug therapy)
• Humans
• Immunosuppressive Agents (adverse effects, therapeutic use)
• Kidney (drug effects)
• Male
• Nephrotic Syndrome (drug therapy, etiology)
• Remission Induction
• Time Factors