Abstract |
Neurotrophin-like immunoreactivity was studied in post-mortem motor cerebral cortex from patients with Amyotrophic Lateral Sclerosis (ALS) and controls. Neurotrophin-4/5 immunoreactivity was seen in small-(12-25 microm), medium-(26-39 microm), and large-(> 40 microm), neurones, neurotrophin-3 was seen in medium and small neurones, while brain-derived neurotrophic factor was restricted to small neurones. No difference in number or intensity of immunostained neurones was found between ALS and controls.
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Authors | R M Duberley, I P Johnson, P Anand, P N Leigh, N J Cairns |
Journal | Brain research
(Brain Res)
Vol. 763
Issue 2
Pg. 259-63
(Jul 25 1997)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 9296568
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Brain-Derived Neurotrophic Factor
- Nerve Growth Factors
- Neuroprotective Agents
- Neurotrophin 3
- neurotrophin 5
- neurotrophin 4
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Topics |
- Aged
- Aged, 80 and over
- Amyotrophic Lateral Sclerosis
(metabolism)
- Brain-Derived Neurotrophic Factor
(analysis)
- Humans
- Immunohistochemistry
- Middle Aged
- Motor Cortex
(chemistry)
- Nerve Growth Factors
(analysis)
- Neuroprotective Agents
(analysis)
- Neurotrophin 3
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