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Immunocytochemical studies of neurotrophins in cerebral motor cortex in Amyotrophic Lateral Sclerosis.

Abstract
Neurotrophin-like immunoreactivity was studied in post-mortem motor cerebral cortex from patients with Amyotrophic Lateral Sclerosis (ALS) and controls. Neurotrophin-4/5 immunoreactivity was seen in small-(12-25 microm), medium-(26-39 microm), and large-(> 40 microm), neurones, neurotrophin-3 was seen in medium and small neurones, while brain-derived neurotrophic factor was restricted to small neurones. No difference in number or intensity of immunostained neurones was found between ALS and controls.
AuthorsR M Duberley, I P Johnson, P Anand, P N Leigh, N J Cairns
JournalBrain research (Brain Res) Vol. 763 Issue 2 Pg. 259-63 (Jul 25 1997) ISSN: 0006-8993 [Print] Netherlands
PMID9296568 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Brain-Derived Neurotrophic Factor
  • Nerve Growth Factors
  • Neuroprotective Agents
  • Neurotrophin 3
  • neurotrophin 5
  • neurotrophin 4
Topics
  • Aged
  • Aged, 80 and over
  • Amyotrophic Lateral Sclerosis (metabolism)
  • Brain-Derived Neurotrophic Factor (analysis)
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Motor Cortex (chemistry)
  • Nerve Growth Factors (analysis)
  • Neuroprotective Agents (analysis)
  • Neurotrophin 3

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