CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells.

Abstract	Dendritic cells initiate immune responses by ferrying antigen from the tissues to the lymphoid organs for presentation to lymphocytes. Little is known about the molecular mechanisms underlying this migratory behavior. We have identified a chemokine receptor which appears to be selectively expressed in human dendritic cells derived from CD34+ cord blood precursors, but not in dendritic cells derived from peripheral blood monocytes. When stably expressed as a recombinant protein in a variety of host cell backgrounds, the receptor shows a strong interaction with only one chemokine among 25 tested: the recently reported CC chemokine macrophage inflammatory protein 3alpha. Thus, we have designated this receptor as the CC chemokine receptor 6. The cloning and characterization of a dendritic cell CC chemokine receptor suggests a role for chemokines in the control of the migration of dendritic cells and the regulation of dendritic cell function in immunity and infection.
Authors	D R Greaves, W Wang, D J Dairaghi, M C Dieu, B Saint-Vis, K Franz-Bacon, D Rossi, C Caux, T McClanahan, S Gordon, A Zlotnik, T J Schall
Journal	The Journal of experimental medicine (J Exp Med) Vol. 186 Issue 6 Pg. 837-44 (Sep 15 1997) ISSN: 0022-1007 [Print] United States
PMID	9294138 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	CCR6 protein, human DNA, Complementary Macrophage Inflammatory Proteins RNA, Messenger Receptors, CCR6 Receptors, Chemokine Receptors, Cytokine Recombinant Proteins
Topics	Amino Acid Sequence Animals Base Sequence CHO Cells Chromosome Mapping Cloning, Molecular Cricetinae DNA, Complementary (genetics) Dendritic Cells (immunology, metabolism) Gene Expression Humans Hybrid Cells Macrophage Inflammatory Proteins (metabolism) Molecular Sequence Data Polymerase Chain Reaction RNA, Messenger (genetics, metabolism) Receptors, CCR6 Receptors, Chemokine Receptors, Cytokine (genetics, metabolism) Recombinant Proteins (genetics, metabolism) Sequence Homology, Amino Acid Transfection

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