Prospective assessment of continuous intrathecal infusion of baclofen for spasticity caused by acquired brain injury: a preliminary report.

Twelve consecutive patients with severe spasticity and hypertonia following acquired brain injury were treated with continuous intrathecal infusion of baclofen via an implanted, programmable infusion pump-catheter system for a minimum of 3 months. In every case intrathecal baclofen therapy resulted in a statistically significant reduction in upper- and lower-extremity tone, spasm frequency, and reflexes, contributing to improved functional abilities. There were no untoward side effects or complications associated with treatment. This preliminary assessment indicates that intrathecal administration of baclofen is effective in treating the disabling spasticity caused by acquired brain injury in selected patients.
AuthorsJ M Meythaler, A McCary, M N Hadley
JournalJournal of neurosurgery (J Neurosurg) Vol. 87 Issue 3 Pg. 415-9 (Sep 1997) ISSN: 0022-3085 [Print] UNITED STATES
PMID9285608 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Muscle Relaxants, Central
  • Baclofen
  • Adolescent
  • Adult
  • Baclofen (administration & dosage)
  • Brain Injuries (complications)
  • Female
  • Humans
  • Infusions, Parenteral
  • Injections, Spinal
  • Male
  • Muscle Relaxants, Central (administration & dosage)
  • Muscle Spasticity (drug therapy, etiology)
  • Prospective Studies
  • Severity of Illness Index
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: