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Prospective assessment of continuous intrathecal infusion of baclofen for spasticity caused by acquired brain injury: a preliminary report.

Abstract
Twelve consecutive patients with severe spasticity and hypertonia following acquired brain injury were treated with continuous intrathecal infusion of baclofen via an implanted, programmable infusion pump-catheter system for a minimum of 3 months. In every case intrathecal baclofen therapy resulted in a statistically significant reduction in upper- and lower-extremity tone, spasm frequency, and reflexes, contributing to improved functional abilities. There were no untoward side effects or complications associated with treatment. This preliminary assessment indicates that intrathecal administration of baclofen is effective in treating the disabling spasticity caused by acquired brain injury in selected patients.
AuthorsJ M Meythaler, A McCary, M N Hadley
JournalJournal of neurosurgery (J Neurosurg) Vol. 87 Issue 3 Pg. 415-9 (Sep 1997) ISSN: 0022-3085 [Print] UNITED STATES
PMID9285608 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Muscle Relaxants, Central
  • Baclofen
Topics
  • Adolescent
  • Adult
  • Baclofen (administration & dosage)
  • Brain Injuries (complications)
  • Female
  • Humans
  • Infusions, Parenteral
  • Injections, Spinal
  • Male
  • Muscle Relaxants, Central (administration & dosage)
  • Muscle Spasticity (drug therapy, etiology)
  • Prospective Studies
  • Severity of Illness Index
  • Treatment Outcome

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