Activation of CD8 T cells with specificity for mycobacterial heat shock protein 60 in Mycobacterium bovis bacillus Calmette-Guérin-vaccinated mice.

Abstract

Heat shock protein 60 (hsp60)-specific CD8 T cells lysed Mycobacterium bovis BCG-infected macrophages in vitro and adoptively transferred protection against mycobacterial infection. Moreover, CD8 T cells with this hsp60 specificity were activated in vivo by BCG vaccination. Our studies suggest there is participation of hsp60-specific CD8 T cells in BCG-induced immunity.

• Authors: U Zügel, S H Kaufmann
• Journal: Infection and immunity (Infect Immun) Vol. 65 Issue 9 Pg. 3947-50 (Sep 1997) ISSN: 0019-9567 [Print] United States
• PMID: 9284177 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• BCG Vaccine
• Chaperonin 60

Topics

• Adoptive Transfer
• Animals
• BCG Vaccine (immunology)
• CD8-Positive T-Lymphocytes (immunology)
• Chaperonin 60 (immunology)
• Cytotoxicity, Immunologic
• Lymphocyte Activation
• Macrophages (immunology, microbiology)
• Mice
• Mycobacterium bovis (immunology)
• Spleen (immunology)
• T-Lymphocytes, Cytotoxic (immunology)