[Menogaril (TUT-7) late phase II study for malignant lymphoma, adult T-cell leukemia and lymphoma (ATLL)].

Abstract

A late Phase II multicenter study with menogaril was conducted nationwide in patients with malignant lymphoma [non-Hodgkin's lymphoma (NHL), Hodgkin's disease (HD)], and ATLL, menogaril was orally administered at 100 mg daily after breakfast, for seven consecutive days with two- or three-week drug withdrawal, then menogaril administration was repeated. For malignant lymphoma, in 81 patients with NHL and 5 patients with HD registered, 70 and 5 patients were evaluable for efficacy, respectively. The efficacy rates were 32.9% (6 CRs + 17 PRs/70) for NHL and 20.0% (1 PR/5) for HD, respectively; that for the NHL patients with prior anthracycline antibiotic chemotherapy was 30.5% (5 CRs and 13 PRs/59). For ATLL, among the 16 patients registered, 15 were evaluable for efficacy, and the efficacy rate was 40.0% (2 CRs and 4 PRs/15). Adverse drug reactions frequently observed in the patients with malignant lymphoma and ATLL included bone-marrow suppression and gastrointestinal symptoms such as anorexia, and nausea/vomiting. With these results, menogaril was considered to be effective for the treatment of non-Hodgkin's lymphoma and ATLL.

• Authors: T Taguchi, K Ohta, T Hotta, S Shirakawa, T Masaoka, I Kimura
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 24 Issue 10 Pg. 1263-71 (Aug 1997) ISSN: 0385-0684 [Print] Japan
• PMID: 9279345 (Publication Type: Clinical Trial, Clinical Trial, Phase II, English Abstract, Journal Article, Multicenter Study)

Chemical References

• Antibiotics, Antineoplastic
• Menogaril

Topics

• Administration, Oral
• Adult
• Aged
• Anorexia (chemically induced)
• Antibiotics, Antineoplastic (administration & dosage, adverse effects)
• Bone Marrow (drug effects)
• Drug Administration Schedule
• Female
• Hodgkin Disease (drug therapy)
• Humans
• Leukemia-Lymphoma, Adult T-Cell (drug therapy)
• Lymphoma, Non-Hodgkin (drug therapy)
• Male
• Menogaril (administration & dosage, adverse effects)
• Middle Aged
• Nausea (chemically induced)
• Vomiting (chemically induced)