[Regional brain calcium change in rabbit cerebral ischemia].

Abstract

OBJECTIVE:

To study whether regional brain calcium change would be an important factor for ischemic neuranal damage and whether calcium antagonist would exert protective effects on cerebral ischemia.

METHODS:

OCPC autoanalyzer method, was used to measure the regional brain calcium and observe the influence of flunarizine (FNZ) 48 hours after the rabbit middle cerebral artery occlusion (MCAO).

RESULTS:

48 hours after MCAO, the calcium in the ischemic middle cerebral artery territory was 10.8 times as much as that in the pseudo-occluded controls, and FNZ could significantly decrease the ischemic brain calcium (P < 0.05) and the ischemic cerebral edema (P < 0.01).

CONCLUSION:

Caoverload was animportant factor leading to ischemic neuronal death, and FNZ has protective effects on cerebral ischemia.

• Authors: W Gu, Q Yang, Y Ou
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 76 Issue 10 Pg. 771-3 (Oct 1996) ISSN: 0376-2491 [Print] China
• PMID: 9275522 (Publication Type: English Abstract, Journal Article)

Chemical References

• Calcium Channel Blockers
• Flunarizine
• Calcium

Topics

• Animals
• Brain (metabolism)
• Brain Ischemia (metabolism)
• Calcium (metabolism)
• Calcium Channel Blockers (pharmacology)
• Flunarizine (pharmacology)
• Rabbits
• Random Allocation