Renal effects of an angiotensin II antagonist in stroke-prone spontaneously hypertensive rat.

Abstract

We evaluated the renal effects of the new angiotensin II type 1 (AT ) receptor antagonist, HR 720, in the stroke-prone spontaneously hypertensive rat. Rats were treated with either vehicle, HR 720, MK-954 (a selective AT1 receptor antagonist) or enalapril for 6 weeks. Blood pressure was decreased to a similar extent by HR 720, MK-954 and enalapril (203 +/- 4, 202 +/- 5 and 190 +/- 4 vs. 247 +/- 4 mm Hg for control). Urinary protein secretion was also decreased (5.2 +/- 0.3, 5.3 +/- 0.2 and 5.5 +/- 0.6 vs. 25.2 +/- 4.6 mg/100g/24h). The glomerular hypertensive change was improved in each drug-treated group (2.0 +/- 0.2, 3.3 +/- 0.3 and 1.6 +/- 0.1 vs. 17.6 +/- 1.5%; p < 0.0001). These results show that, in addition to its antihypertensive effect, HR 720 has a beneficial effect on renal function.

• Authors: Y Yo, A Moriguchi, J Higaki, M Nagano, N Nakano, K Kamide, H Yu, H Mikami, T Ogihara
• Journal: Nephron (Nephron) Vol. 76 Issue 4 Pg. 466-71 ( 1997) ISSN: 1660-8151 [Print] Switzerland
• PMID: 9274845 (Publication Type: Journal Article)

Chemical References

• Angiotensin Receptor Antagonists
• Biphenyl Compounds
• Imidazoles
• Receptors, Angiotensin
• Tetrazoles
• fonsartan
• Angiotensin II
• Angiotensin I
• Losartan

Topics

• Angiotensin I (antagonists & inhibitors, metabolism)
• Angiotensin II (antagonists & inhibitors, metabolism)
• Angiotensin Receptor Antagonists
• Animals
• Biphenyl Compounds (pharmacology)
• Blood Pressure (drug effects)
• Body Weight (drug effects)
• Cerebrovascular Disorders (genetics, physiopathology)
• Dose-Response Relationship, Drug
• Heart Rate (drug effects)
• Hypertension (genetics, physiopathology)
• Imidazoles (pharmacology)
• Kidney (drug effects)
• Kidney Function Tests
• Kidney Glomerulus (drug effects, ultrastructure)
• Losartan
• Organ Size (drug effects)
• Proteinuria (drug therapy, urine)
• Rats
• Rats, Inbred SHR
• Receptors, Angiotensin (metabolism)
• Tetrazoles (pharmacology)
• Tissue Embedding