Abstract |
The effects of dietary supplementation by blackcurrant seed oil (BSO) and zinc sulphate on PGI2 gastric release and on serum zinc levels were investigated in 50 pregnant Sprague-Dawley rats which received watery alcohol solutions from 5% to 30% (v/v) as well as in their newborns. Blood zinc was assayed by atomic absorption spectroscopy; PGI2 was evaluated by platelet aggregation PGI2-dependent test. Dietary supplementation by BSO increased gastric release of PGI2 both in the mothers and their newborns; blood zinc levels were significantly (p < 0.01) lower in both vs control. The content of PGI2 in the stomachs was significantly (p < 0.01) higher in the mothers treated by zinc sulphate vs their new-borns. Protection of gastric mucosa of the new-born rats from alcohol fetal exposure might depend on polyunsaturated fatty acids (PUFA) dietary supplementation, because of the capability of PUFA to cross placenta; the efficacy in the protection might be monitored by platelet aggregation PGI2-dependent test.
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Authors | S Seri, A D'Alessandro |
Journal | Bollettino della Societa italiana di biologia sperimentale
(Boll Soc Ital Biol Sper)
1997 Jan-Feb
Vol. 73
Issue 1-2
Pg. 15-21
ISSN: 0037-8771 [Print] Italy |
PMID | 9270175
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Linolenic Acids
- Plant Oils
- blackcurrant seed oil
- Ethanol
- Zinc Sulfate
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Topics |
- Administration, Oral
- Animals
- Disease Models, Animal
- Ethanol
(administration & dosage, adverse effects, pharmacology)
- Female
- Fetal Alcohol Spectrum Disorders
(blood, drug therapy, prevention & control)
- Linolenic Acids
(administration & dosage, pharmacology)
- Plant Oils
(administration & dosage, pharmacology)
- Pregnancy
- Rats
- Rats, Sprague-Dawley
- Zinc Sulfate
(administration & dosage, blood, pharmacology)
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