Abstract |
Effect of subchronically administered GTS-21 [3-(2,4-dimethoxybenzylidene)- anabaseine dihydrochloride], a selective nicotinic agonist, on neuronal cell loss caused by nucleus basalis magnocellularis (nBM) lesion was studied in rats. After 2 weeks of bilateral nBM excitotoxic lesion, GTS-21 was orally administered once daily for 20 weeks. Neuronal cell loss was observed in layers II-III of the parietal cortex in the lesioned control rats. GTS-21 significantly attenuated the neuron loss in these layers. These results suggest that GTS-21 exhibits a protective action against the neuronal cell death in the parietal cortex and may have a beneficial effect on neurodegenerative disorders such as an Alzheimer-type disease.
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Authors | M Nanri, N Kasahara, J Yamamoto, H Miyake, H Watanabe |
Journal | Japanese journal of pharmacology
(Jpn J Pharmacol)
Vol. 74
Issue 3
Pg. 285-9
(Jul 1997)
ISSN: 0021-5198 [Print] Japan |
PMID | 9268090
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Benzylidene Compounds
- Neuroprotective Agents
- Nicotinic Agonists
- Pyridines
- Nicotine
- 3-(2,4-dimethoxybenzylidene)anabaseine
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Topics |
- Animals
- Benzylidene Compounds
(pharmacology)
- Cell Death
- Cerebral Cortex
(drug effects, physiopathology)
- Male
- Neurons
(drug effects)
- Neuroprotective Agents
(pharmacology)
- Nicotine
(pharmacology)
- Nicotinic Agonists
(pharmacology)
- Pyridines
(pharmacology)
- Rats
- Rats, Wistar
- Substantia Innominata
(physiopathology)
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