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GTS-21, a nicotinic agonist, protects against neocortical neuronal cell loss induced by the nucleus basalis magnocellularis lesion in rats.

Abstract
Effect of subchronically administered GTS-21 [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], a selective nicotinic agonist, on neuronal cell loss caused by nucleus basalis magnocellularis (nBM) lesion was studied in rats. After 2 weeks of bilateral nBM excitotoxic lesion, GTS-21 was orally administered once daily for 20 weeks. Neuronal cell loss was observed in layers II-III of the parietal cortex in the lesioned control rats. GTS-21 significantly attenuated the neuron loss in these layers. These results suggest that GTS-21 exhibits a protective action against the neuronal cell death in the parietal cortex and may have a beneficial effect on neurodegenerative disorders such as an Alzheimer-type disease.
AuthorsM Nanri, N Kasahara, J Yamamoto, H Miyake, H Watanabe
JournalJapanese journal of pharmacology (Jpn J Pharmacol) Vol. 74 Issue 3 Pg. 285-9 (Jul 1997) ISSN: 0021-5198 [Print] Japan
PMID9268090 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Benzylidene Compounds
  • Neuroprotective Agents
  • Nicotinic Agonists
  • Pyridines
  • Nicotine
  • 3-(2,4-dimethoxybenzylidene)anabaseine
Topics
  • Animals
  • Benzylidene Compounds (pharmacology)
  • Cell Death
  • Cerebral Cortex (drug effects, physiopathology)
  • Male
  • Neurons (drug effects)
  • Neuroprotective Agents (pharmacology)
  • Nicotine (pharmacology)
  • Nicotinic Agonists (pharmacology)
  • Pyridines (pharmacology)
  • Rats
  • Rats, Wistar
  • Substantia Innominata (physiopathology)

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