[The efficacy of and tolerance for ketoprofen lysine salt in solution for oropharyngeal use in inflammatory lesions of the oral cavity].

Abstract

BACKGROUND:

A double blind randomized comparative clinical study vs placebo clinical study has been carried out in order to assess the antiinflammatory and analgesic activity of ketoprofen lysine salt in oropharyngeal solution, in pain-inflammatory pathologies of odontostomatological nature.

METHODS:

One hundred and twenty patients, aged between 18 and 82 years, were recruited for the purpose and assigned at random to treatment with ketoprofen lysine salt or placebo for a period of 7 days.

RESULTS AND CONCLUSIONS:

Treatment with ketoprofen lysine salt demonstrated a significantly more marked (p < 0.001) anti-inflammatory effect than placebo as regards all variables considered: burning, sensation pain, oedema and erythema, and by the 3rd day of treatment led to significant remission of the symptomatology. Tolerability of ketoprofen lysine salt was excellent.

• Authors: F Natale, C de' Lorenzi
• Journal: Minerva stomatologica (Minerva Stomatol) Vol. 46 Issue 5 Pg. 273-8 (May 1997) ISSN: 0026-4970 [Print] Italy
• Vernacular Title: Efficacia e tollerabilità di ketoprofene sale di lisina in soluzione per uso orofaringeo nelle affezioni flogistiche del cavo orale.
• PMID: 9265098 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Mouthwashes
• ketoprofen lysine
• Ketoprofen
• Lysine

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Double-Blind Method
• Drug Tolerance
• Female
• Humans
• Ketoprofen (analogs & derivatives, therapeutic use)
• Lysine (analogs & derivatives, therapeutic use)
• Male
• Middle Aged
• Mouthwashes (therapeutic use)
• Remission Induction
• Stomatitis (drug therapy)