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Ankylosing spondylitis with selective IgA deficiency and a circulating anticoagulant.

Abstract
A patient with ankylosing spondylitis was found to have selective IgA deficiency and a non-heparin, immediate-acting antithrombin (antithrombin V). T cells were decreased, and serum IgG was increased. In vitro synthesis of IgG by peripheral blood lymphocytes was very high. This association of ankylosing spondylitis with the T cell and protein abnormalities is probably fortuitous but does demonstrate that severe spondylitis may evolve in the absence of IgA.
AuthorsA E Good, J T Cassidy, M G Mutchnick, R E Reed, H M Lederman
JournalThe Journal of rheumatology (J Rheumatol) Vol. 4 Issue 3 Pg. 297-302 ( 1977) ISSN: 0315-162X [Print] Canada
PMID926106 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antithrombins
  • HLA Antigens
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
Topics
  • Antithrombins (analysis)
  • Blood Coagulation
  • Dysgammaglobulinemia (blood, complications)
  • HLA Antigens (analysis)
  • Humans
  • Immunoglobulin A (analysis)
  • Immunoglobulin G (analysis)
  • Immunoglobulin M (analysis)
  • Lymphocyte Activation
  • Lymphocytes (immunology)
  • Male
  • Middle Aged
  • Spondylitis, Ankylosing (blood, complications, immunology)

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