Familial aggregation of malignant melanoma/dysplastic naevi and tumours of the nervous system: an original syndrome of tumour proneness.

Abstract

A five-generation family is here reported in which several members developed malignant melanoma, dysplastic naevi, astrocytoma in all grades, benign or malignant schwannoma, neurofibroma, or meningioma in a single instance. Significant cosegregation of skin and nervous tumours, preclusion of allelism to type 1 neurofibromatosis and phenotypic departure from known syndromes of hereditary proneness to cancer make one suggest an original familial predisposition to both malignant melanoma and central/peripheral nervous tumours.

• Authors: M Bahuau, D Vidaud, M Kujas, A Palangié, B Assouline, M Chaignaud-Lebreton, M Prieur, M Vidaud, J P Harpey, J Lafourcade, B Caille
• Journal: Annales de genetique (Ann Genet) Vol. 40 Issue 2 Pg. 78-91 ( 1997) ISSN: 0003-3995 [Print] Netherlands
• PMID: 9259954 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Child
• Dysplastic Nevus Syndrome (genetics)
• Female
• Genetic Predisposition to Disease
• Humans
• Karyotyping
• Male
• Melanoma (genetics)
• Nervous System Neoplasms (genetics)
• Pedigree
• Polymorphism, Genetic
• Skin Neoplasms (genetics)
• Syndrome