Fibrin deposition in the central nervous system correlates with the degree of Theiler's murine encephalomyelitis virus-induced demyelinating disease.

Abstract

We examined the role of coagulation-fibrinolysis system in Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD). The degree of fibrin deposition around the vessels in the spinal cord was significantly higher in susceptible SJL/J mice on 30 days post intracerebral injection (i.c.) than resistant C57BL/6 mice on 30 days post i.c. or mock infected SJL/J mice. Treatment with batroxobin (30 BU/kg/day), which is a thrombin-like defibrinogenating enzyme, causing a profound degree of afibrinogenemia, suppressed clinical signs of TMEV-IDD. Plasma fibrinogen concentration was significantly decreased in batroxobin-treated mice. Histologically, though the degree of perivascular mononuclear cell infiltration in the spinal cord was not suppressed in batroxobin-treated mice compared to saline-treated control mice, fibrin deposition was markedly suppressed in batroxobin-treated mice. These findings suggest that batroxobin suppresses TMEV-IDD through its defibrination effect, and provide evidence that CNS-associated deposition of fibrin and ensuing fibrinolysis, together with increased permeability of the blood-brain barrier (BBB), are prerequisite events for clinical manifestations of TMEV-IDD.

• Authors: A Inoue, C S Koh, M Yamazaki, N Yanagisawa, Y Ishihara, B S Kim
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 77 Issue 2 Pg. 185-94 (Aug 1997) ISSN: 0165-5728 [Print] Netherlands
• PMID: 9258249 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Viral
• Sodium Chloride
• Fibrin

Topics

• Animals
• Antibodies, Viral (biosynthesis)
• Demyelinating Diseases (immunology, metabolism, pathology, virology)
• Disease Susceptibility
• Female
• Fibrin (immunology, metabolism)
• Hypersensitivity, Delayed (immunology, virology)
• Injections, Intraperitoneal
• Injections, Intraventricular
• Mice
• Mice, Inbred C57BL
• Mice, Inbred Strains
• Poliomyelitis (immunology, metabolism, pathology)
• Sodium Chloride (pharmacology)
• Spinal Cord (immunology, metabolism, pathology)
• T-Lymphocytes (drug effects, immunology, virology)
• Theilovirus (immunology)