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Allogeneic bone marrow transplantation for Alexander's disease.

Abstract
In this case report, we evaluate the efficacy of allogeneic bone marrow transplantation (BMT) in a 7-month-old female with the infantile form of Alexander's disease. Based on research that describes Alexander's disease as a leukodystrophy which may result from an unidentified enzyme deficiency, we attempted marrow transplantation to reverse or arrest the patient's neurological deterioration. Despite an initial return to her pretransplant neurological state, the patient's neurological status deteriorated. Marrow transplantation was not effective in changing her prognosis with Alexander's disease.
AuthorsM J Staba, S Goldman, F L Johnson, P R Huttenlocher
JournalBone marrow transplantation (Bone Marrow Transplant) Vol. 20 Issue 3 Pg. 247-9 (Aug 1997) ISSN: 0268-3369 [Print] England
PMID9257894 (Publication Type: Case Reports, Journal Article)
Topics
  • Bone Marrow Transplantation
  • Demyelinating Diseases (pathology, physiopathology, therapy)
  • Female
  • Humans
  • Infant
  • Transplantation, Homologous

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