Abstract | BACKGROUND: METHODS: RESULTS: Urinary concentrations of deoxypyridinoline (pmol/micromol creatinine) in patients with prostatic carcinoma and bone metastases (10.4 +/- 7.7) were significantly higher than those in similar patients without bone metastases (4.3 +/- 1.3) and those in patients with benign prostatic hyperplasia (3.8 +/- 1.2). Serum levels of P1CP and 1CTP (ng/mL) in patients with prostatic carcinoma and bone metastases (262.6 +/- 188.7 and 10.3 +/- 9.5, respectively) were significantly higher than those in similar patients without bone metastases (118.1 +/- 30.2 and 4.3 +/- 1.4, respectively) and those in patients with benign prostatic hyperplasia (93.9 +/- 25.1 and 3.3 +/- 1.1, respectively). Serial measurements of urinary deoxypyridinoline and serum P1CP and 1CTP were correlated with a positive response to treatment (reduced measurements) and with the clinical progression of disease (increased measurements) before detection of new bone lesions by bone scintigram. CONCLUSION:
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Authors | S Takeuchi, H Saitoh |
Journal | International journal of urology : official journal of the Japanese Urological Association
(Int J Urol)
Vol. 4
Issue 4
Pg. 368-73
(Jul 1997)
ISSN: 0919-8172 [Print] Australia |
PMID | 9256326
(Publication Type: Journal Article)
|
Chemical References |
- Amino Acids
- Biomarkers
- Procollagen
- deoxypyridinoline
- Collagen
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Topics |
- Aged
- Amino Acids
(urine)
- Biomarkers
- Bone Neoplasms
(secondary)
- Bone Resorption
(metabolism)
- Collagen
(blood)
- Disease Progression
- Humans
- Male
- Middle Aged
- Predictive Value of Tests
- Procollagen
(blood)
- Prostatic Neoplasms
(pathology)
- Recurrence
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