Abstract |
In this study, we summarize 47 epidemiologic studies related to formaldehyde exposure and use meta-analytic techniques to assess findings for cancers of the lung, nose/nasal sinuses, and nasopharynx. Our analyses indicate that workers with formaldehyde exposure have essentially null findings for lung cancer and a slight deficit of sinonasal cancer. Nasopharyngeal cancer rates were elevated moderately in a minority of studies. Most studies, however, did not find any nasopharyngeal cancers, and many failed to report their findings. After correcting for underreporting, we found a meta relative risk of 1.0 for cohort studies. Case-control studies had a meta relative risk of 1.3. Our review of the exposure literature indicated that the nasopharyngeal cancer case-control studies represented much lower and less certain exposures than the cohort studies. We conclude that the available studies do not support a causal relation between formaldehyde exposure and nasopharyngeal cancer. This conclusion conflicts with conclusions from two previous meta-analyses, primarily because of our consideration of unreported data.
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Authors | J J Collins, J F Acquavella, N A Esmen |
Journal | Journal of occupational and environmental medicine
(J Occup Environ Med)
Vol. 39
Issue 7
Pg. 639-51
(Jul 1997)
ISSN: 1076-2752 [Print] United States |
PMID | 9253725
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carcinogens, Environmental
- Formaldehyde
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Topics |
- Carcinogens, Environmental
(adverse effects)
- Female
- Formaldehyde
(adverse effects)
- Humans
- Male
- Occupational Diseases
(chemically induced, epidemiology)
- Respiratory Tract Neoplasms
(chemically induced, epidemiology)
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