Abstract |
The objective of this study was to determine the effect of ethyl eicosopentate (EPA-E) on local cerebral blood flow (1-CBF) and local glucose utilization (1-CGU) in specific regions of the brain in stroke-prone spontaneously hypertensive rats (SHRSP). EPA-E (100 mg/kg body weight) or saline was orally administered to 8-week-old SHRSP. L-CBF and 1-CGU in the EPA-E-treated, saline-treated, and 8-week-old control rats were measured autoradiographically using 14C-iodoantipyrine and 14C-deoxyglucose (Sakurada's and Sokoloff's methods). The 1-CBF of the saline-treated group decreased significantly with age in all areas measured. EPA-E treatment alleviated the age-dependent decrease in 1-CBF in all areas, especially those in the basal ganglia. The 1-CGU of the saline-treated group did not change with age, however EPA-E treatment increased 1-CGU in all areas measured, though the changes were not significant. EPA-E ameliorated the decrease in cerebral blood flow and improved glucose metabolism in SHRSP suffering from severe hypertension. These results suggest that EPA-E may be useful in the prevention of stroke.
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Authors | Y Katayama, T Katsumata, H Muramatsu, K Usuda, R Obo, A Terashi |
Journal | Brain research
(Brain Res)
Vol. 761
Issue 2
Pg. 300-5
(Jul 04 1997)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 9252029
(Publication Type: Journal Article)
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Chemical References |
- Platelet Aggregation Inhibitors
- eicosapentaenoic acid ethyl ester
- Eicosapentaenoic Acid
- Glucose
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Topics |
- Animals
- Autoradiography
- Blood Pressure
- Brain
(blood supply, metabolism)
- Cerebrovascular Circulation
(drug effects)
- Eicosapentaenoic Acid
(analogs & derivatives, pharmacology)
- Glucose
(metabolism)
- Heart Rate
- Male
- Platelet Aggregation Inhibitors
(pharmacology)
- Rats
- Rats, Inbred SHR
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