Treatment of metastatic uterine leiomyosarcoma with cisplatin, pirarubicin, and ifosfamide.

Abstract

We present the unusual case of a 27-year-old Japanese woman who exhibited recurrences of metastatic tumors from uterine leiomyosarcoma after five operations. Chemotherapy with cisplatin, pirarubicin, and cyclophosphamide was ineffective. Substituting ifosfamide for cyclophosphamide, we obtained a complete response. The Gynecologic Oncology Group (GOG) in the United States has recognized the efficacy of ifosfamide and mesna in the treatment of patients with advanced or recurrent uterine sarcomas. Here we report on the efficacy of ifosfamide in addition to cisplatin and pirarubicin.

• Authors: Y Hirota, K Miyamura, T Hayata, I Miyakawa
• Journal: Gynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 44 Issue 1 Pg. 70-2 ( 1997) ISSN: 0378-7346 [Print] Switzerland
• PMID: 9251960 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents
• Doxorubicin
• pirarubicin
• Cisplatin
• Ifosfamide

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cisplatin (administration & dosage)
• Doxorubicin (administration & dosage, analogs & derivatives)
• Female
• Humans
• Ifosfamide (administration & dosage)
• Immunosuppressive Agents
• Leiomyosarcoma (drug therapy, pathology)
• Neoplasm Recurrence, Local
• Remission Induction
• Uterine Neoplasms (drug therapy, pathology)