Combination of subtotal perineoplasty and interferon for the treatment of vulvar vestibulitis.

Abstract

PURPOSE:

To evaluate the efficacy of a combination of subtotal perineoplasty and interferon (IFN) infiltration of the remaining anterior vestibule in the treatment of vulvar vestibulitis.

BASIC PROCEDURES:

Nineteen women with vulvar vestibulitis were randomized to undergo either a total perineoplasty or a subtotal perineoplasty without removal of the anterior vestibule. The second group was further treated 6 weeks later with injection of the anterior vestibule by IFN. Differences in outcome between the groups were analyzed using Fisher's exact test.

MAIN FINDINGS:

The combination of subtotal perineoplasty and IFN injections was successful in 7 of 10 women, similar to the outcome of the group undergoing total perineoplasty (6 of 9 patients).

CONCLUSION:

A combination of subtotal perineoplasty and IFN injections to the anterior vestibule is as effective as total perineoplasty and has less surgical complications.

• Authors: J Bornstein, H Abramovici
• Journal: Gynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 44 Issue 1 Pg. 53-6 ( 1997) ISSN: 0378-7346 [Print] Switzerland
• PMID: 9251955 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Interferon alpha-2
• Interferon-alpha
• Recombinant Proteins

Topics

• Adolescent
• Adult
• Combined Modality Therapy
• Dyspareunia (etiology, therapy)
• Female
• Humans
• Interferon alpha-2
• Interferon-alpha (administration & dosage, therapeutic use)
• Recombinant Proteins
• Treatment Outcome
• Vulvitis (complications, surgery, therapy)