Abstract |
The numbers of argyrophilic nucleolar organizer regions ( AgNORs) were quantified in oral carcinomas (n = 39) with or without human papillomavirus (HPV) infection. The AgNOR counts of the HPV-positive samples (7.15 +/- 2.13) were not significantly (P = 0.09) higher than those of the HPV-negative ones (6.16 +/- 1.89). Furthermore, the lesions infected with multiple HPV types had greater counts than those with HPV type 16/18 infection alone. Significant differences were observed between the mean counts of the poorly (10.50 +/- 0.54), moderately (7.31 +/- 1.07) and well- (5.12 +/- 0.85) differentiated carcinomas. The mean AgNOR numbers in the oral carcinomas at TNM stages III/IV were found to be significantly (P < 0.01) higher than the numbers in corresponding stage II lesions. Cytokinetics of the lesions assessed by the bromodeoxyuridine ( Brdu) labelling index (LI%) showed a linear correlation (r = 0.91; P < 0.0001) with their respective mean AgNOR counts.
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Authors | R Chatterjee, D Mukhopadhyay, R N Chakraborty, R B Mitra |
Journal | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
(J Oral Pathol Med)
Vol. 26
Issue 7
Pg. 310-4
(Aug 1997)
ISSN: 0904-2512 [Print] Denmark |
PMID | 9250930
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Bromodeoxyuridine
(analysis)
- Cell Division
- Female
- Humans
- In Situ Hybridization
- Male
- Middle Aged
- Mouth Neoplasms
(complications, pathology, ultrastructure)
- Nucleolus Organizer Region
(ultrastructure)
- Papillomaviridae
(isolation & purification)
- Papillomavirus Infections
(complications)
- Prognosis
- Silver Staining
- Tumor Virus Infections
(complications)
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