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Evaluation of argyrophilic nucleolar organizer regions (AgNORs) in oral carcinomas in relation to human papillomavirus infection and cytokinetics.

Abstract
The numbers of argyrophilic nucleolar organizer regions (AgNORs) were quantified in oral carcinomas (n = 39) with or without human papillomavirus (HPV) infection. The AgNOR counts of the HPV-positive samples (7.15 +/- 2.13) were not significantly (P = 0.09) higher than those of the HPV-negative ones (6.16 +/- 1.89). Furthermore, the lesions infected with multiple HPV types had greater counts than those with HPV type 16/18 infection alone. Significant differences were observed between the mean counts of the poorly (10.50 +/- 0.54), moderately (7.31 +/- 1.07) and well- (5.12 +/- 0.85) differentiated carcinomas. The mean AgNOR numbers in the oral carcinomas at TNM stages III/IV were found to be significantly (P < 0.01) higher than the numbers in corresponding stage II lesions. Cytokinetics of the lesions assessed by the bromodeoxyuridine (Brdu) labelling index (LI%) showed a linear correlation (r = 0.91; P < 0.0001) with their respective mean AgNOR counts.
AuthorsR Chatterjee, D Mukhopadhyay, R N Chakraborty, R B Mitra
JournalJournal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 26 Issue 7 Pg. 310-4 (Aug 1997) ISSN: 0904-2512 [Print] Denmark
PMID9250930 (Publication Type: Journal Article)
Chemical References
  • Bromodeoxyuridine
Topics
  • Adult
  • Aged
  • Bromodeoxyuridine (analysis)
  • Cell Division
  • Female
  • Humans
  • In Situ Hybridization
  • Male
  • Middle Aged
  • Mouth Neoplasms (complications, pathology, ultrastructure)
  • Nucleolus Organizer Region (ultrastructure)
  • Papillomaviridae (isolation & purification)
  • Papillomavirus Infections (complications)
  • Prognosis
  • Silver Staining
  • Tumor Virus Infections (complications)

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