Protective effects of a novel quinone derivative, E3330, on mouse hepatitis virus (MHV)-induced chronic hepatitis in athymic nude mice.

Abstract

In this experiment, we examined the protective effects of a novel quinone derivative, E3330, on MHV-2cc-induced chronic hepatitis in athymic nude mice for up to 3 weeks after virus infection. The daily dose of 25 mg/kg b.w. suppressed the viral replication in the liver and the progression of hepatic lesions. The expansion of small focal lesions at 1 week after viral inoculation (WAI) was suppressed at 2 WAI, and the lesions were still small at 3 WAI in E3330-administered group, whereas small focal lesions at 1 WAI were expanded at 2 WAI to fuse with each other at 3 WAI in the control group. E3330 therefore showed protective effects on MHV-2cc-induced chronic hepatitis in athymic nude mice, but further studies are needed to analyze the mechanism.

• Authors: K Uetsuka, M Suzuki, C Kai, N Goto
• Journal: Experimental animals (Exp Anim) Vol. 46 Issue 3 Pg. 219-23 (Jul 1997) ISSN: 1341-1357 [Print] Japan
• PMID: 9250483 (Publication Type: Journal Article)

Chemical References

• Benzoquinones
• Interferon Type I
• Propionates
• Recombinant Proteins
• E 3330
• Interferon-gamma

Topics

• Administration, Oral
• Animals
• Benzoquinones (pharmacology)
• Chronic Disease
• Coronavirus Infections (pathology, prevention & control)
• Female
• Hepatitis, Viral, Animal (pathology, prevention & control)
• Interferon Type I (pharmacology)
• Interferon-gamma (pharmacology)
• Liver (drug effects, pathology, virology)
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Murine hepatitis virus (isolation & purification)
• Propionates (pharmacology)
• Recombinant Proteins
• Virus Replication (drug effects)