HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Superovulation combined with insemination or timed intercourse in the treatment of couples with unexplained infertility and minimal endometriosis.

AbstractBACKGROUND:
To compare intrauterine insemination (IUI), direct intraperitoneal insemination (DIPI), and timed-intercourse (TI), each combined with superovulation, in the treatment of couples with unexplained infertility, including couples with minimal endometriosis.
METHODS:
A retrospective analysis of 233 superovulation cycles in 70 couples with unexplained infertility or minimal endometriosis. Stimulation protocol, pregnancy rate, pregnancy outcome, and complications of treatment were analyzed.
RESULTS:
The pregnancy rare was 8.6% per cycle and 28.5% per couple. A majority of all treatment pregnancies (85%) occurred during the first four cycles of treatment. The duration of infertility did not influence the pregnancy rate. The pregnancy rate in patients with unexplained infertility was higher, but not significantly, than in patients with minimal endometriosis (27.7% versus 18.4%). No predictive marker for successful stimulation was found, except for the higher luteal progesterone level in cycles resulting in pregnancy. The multiple pregnancy rate was high: 30% of all pregnancies and 40% of all deliveries were multiple.
CONCLUSIONS:
Superovulation in combination with insemination or intercourse is effective and is still recommended in the treatment of couples with unexplained infertility.
AuthorsR Isaksson, A Tiitinen
JournalActa obstetricia et gynecologica Scandinavica (Acta Obstet Gynecol Scand) Vol. 76 Issue 6 Pg. 550-4 (Jul 1997) ISSN: 0001-6349 [Print] United States
PMID9246961 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Chorionic Gonadotropin
  • Clomiphene
Topics
  • Adult
  • Chorionic Gonadotropin (administration & dosage)
  • Clomiphene (administration & dosage)
  • Endometriosis (complications)
  • Female
  • Humans
  • Infertility, Female (etiology, therapy)
  • Infertility, Male
  • Insemination, Artificial, Homologous (methods)
  • Male
  • Ovarian Hyperstimulation Syndrome (complications)
  • Pregnancy
  • Sperm Count
  • Sperm Motility

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: