[The role of Shigella dysenteriae toxin formation at different stages in the forming of the cellular immune response in experimental animals].

Abstract

The immunomodulating action of genetically related pairs of strains of S. dysenteriae 1, differing by the presence of high molecular plasmid with a mol. wt. of 140 mD and transposon-mediated mutation in the tox-gene chromosome (4 phenotypes: Inv+ Tox+; Inv+ Tox-; Inv- Tox+; Inv- Tox-), was studied. The study was carried out with the use of the experimental intraperitoneal infection of CBA mice with live Shigella cells in a dose of 5x10(7) microbial cells. For the first time the role of Shiga toxin synthesis at different stages of the formation of cell-mediated immune response was demonstrated in vivo. This response was manifested by the stimulation of hematopoiesis, pronounced sensitization of effectors of delayed hypersensitivity and an immunomodulating effect on immunocompetent B lymphocytes, synthesizing antibodies, specific to S. dysenteriae 1 LPS and non-specific to heterologous antigen (sheep red blood cells).

• Authors: T N Nikolaeva, V M Bondarenko, A V Pronin
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) 1997 Mar-Apr Issue 2 Pg. 6-10 ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Rol' toksinoobrazovaniia Shigella dysenteriae na razlichnykh étapakh formirovaniia kletochnogo immunnogo otveta éksperimental'nykh zhivotnykh.
• PMID: 9245145 (Publication Type: Journal Article)

Chemical References

• Bacterial Toxins
• Exotoxins
• Shiga Toxins

Topics

• Animals
• B-Lymphocytes
• Bacterial Toxins (biosynthesis, immunology)
• Dysentery, Bacillary (immunology)
• Exotoxins (biosynthesis, immunology)
• Immunity, Cellular
• Male
• Mice
• Mice, Inbred CBA
• Mutation
• Shiga Toxins
• Shigella dysenteriae (immunology, pathogenicity)
• T-Lymphocytes (immunology)
• Time Factors