[Modulation of the antitumor effect of cyclophosphamide by the recombinant probiotic Subalin].
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| Abstract |
A new preparation "subalin" developed on the basis of a recombinant saprophyte strain of Bacillus subtilis 2135/105 producing human interferon alpha-2 has been tested for its ability of increasing the effectiveness of antitumor therapy. The study used Lewis lung carcinoma bearing mice C57B1/6 treated with injections of 60 mg/kg body cyclophosphamide, intraperitoneally, on days 3 and 7 of tumor growth. Subalin was administered per as on days 1-14 after tumor transplantation. Combined treatment with cyclophosphamide and subalin resulted in a significantly higher inhibition of primary tumor growth and metastatic spreading as compared with control receiving cyclophosphamide alone. Also, there were fewer animals with metastasis; the average number of these lesions per animal and the total affected area were less. Subalin proved to exert a moderate antitumor and antimetastatic effect. The cytostatic activity of peritoneal macrophages was higher in mice treated with subalin. It is suggested that the chemo-sensitizing and antitumor effects of subalin are due to its ability to induce endogenous interferon production.
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| Authors | N V Cherdyntseva, N V Litviakov, E S Smol'ianinov, V A Beliavskaia, V I Masycheva |
| Journal | Voprosy onkologii (Vopr Onkol) Vol. 43 Issue 3 Pg. 313-6 ( 1997) ISSN: 0507-3758 [Print] Russia (Federation) |
| Vernacular Title | Moduliatsiia protivoopukholevoĭ aktivnosti tsiklofosfana rekombinantnym probiotikom Subalinom. |
| PMID | 9245089 (Publication Type: English Abstract, Journal Article) |
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