[Prognostic value of insulin-like growth factor I-IGF-I--and its binding protein IGFBP-3 in alcoholic liver disease].

Abstract

IGF-I is a single polypeptide chain with important anabolic and endocrine activities. The liver is the major source of IGF-I and its binding protein, IGFBP-3. Circulating concentrations of IGF-I and IGFBP-3 are decreased in patients with chronic liver disease and correlate with the severity. The aim of this study was to assess the additional prognostic value of IGF-I and IGFBP-3 in patients entered in a large multicentre study (EMALD). Three hundred and thirty-seven patients with alcoholic liver disease were studied in a randomised placebo-controlled trial of malotilate with a mean follow-up period of 569 days (range: 7-1544). A multivariate Cox regression analysis of pertinent clinical and biochemical variables revealed a significant independent prognostic value of years of alcohol intake, coagulation factors 2, 7, and 10, alkaline phosphatases, serum creatinine, and immunoglobulin M (IGM). When IGF-I or IGFBP-3 were added into this model, a Cox regression analysis showed that either had a significant independent prognostic value. As IGF-I and IGFBP-3 were closely correlated, they contained almost the same prognostic information. Inclusion of IGF-I gave these results: IGF-I (p < 0.03), alcohol intake (p < 0.02), coagulation factors 2, 7, and 10 (p < 0.01), creatinine (p < 0.001), and IgM (p < 0.01) contained independent prognostic information. Inclusion of IGFBP-3 gave these results: IGFBP-3 (p < 0.02), alcohol intake (p < 0.05), coagulation factor 2, 7, and 10 (p < 0.01), creatinine (p < 0.001), and IgM (p < 0.02) were independent predictors of survival. In conclusion IGF-I or IGFBP-3 provides important additional information on survival in patients with alcoholic liver disease.

• Authors: S Møller, P U Becker, A Juul, N E Skakkebaek, E Christensen
• Journal: Ugeskrift for laeger (Ugeskr Laeger) Vol. 159 Issue 30 Pg. 4636-40 (Jul 21 1997) ISSN: 0041-5782 [Print] Denmark
• Vernacular Title: Den prognostiske vaerdi af insulinlignende vaekstfaktor I-IGF-I--og bindingsproteinet IGFBP-3 ved alkoholisk leversygdom. EMALD-gruppen.
• PMID: 9245039 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Insulin-Like Growth Factor Binding Protein 3
• Malonates
• Insulin-Like Growth Factor I
• diisopropyl 1,3-dithiol-2-ylidenemalonate

Topics

• Adult
• Aged
• Female
• Follow-Up Studies
• Humans
• Insulin-Like Growth Factor Binding Protein 3 (analysis)
• Insulin-Like Growth Factor I (analysis)
• Liver Diseases, Alcoholic (blood, mortality)
• Male
• Malonates (therapeutic use)
• Middle Aged
• Prognosis
• Prospective Studies