[The structure of the connective-tissue framework of the skin regenerate in rats during the trypsin and ronidase stimulation of wound healing].

Abstract

Peculiarities of formation of connective tissue framework of granulation tissue and scar were studied using light optical and scanning electron microscopy in rats during all-layer skin wound healing in interscapular region. Formation of granulation tissue and scar was accelerated after daily 20 minutes treatment with 0.2% trypsin and 0.1% ronidase solutions as compared to that in control. Regenerates are characterized by different morphological properties. Trypsin promotes quick formation of collagen fibre fascicles with their following thickening and gradual exfoliation. Ronidase action leads to small diameter collagen fibres formation and their following organization into larger fascicles. The peculiarities established are associated with different mechanisms of enzyme effect on reparative processes.

• Authors: T V Surakova, P P Ivanishchuk, A A Mironov, V A Stroganov
• Journal: Morfologiia (Saint Petersburg, Russia) (Morfologiia) Vol. 111 Issue 2 Pg. 76-9 ( 1997) ISSN: 1026-3543 [Print] Russia (Federation)
• Vernacular Title: Stroenie soedinitel'notkannogo karkasa kozhnogo regenerata u krys pri stimuliatsii zazhivleniia rany tripsinom i ronidazoĭ.
• PMID: 9244556 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hexosaminidases
• ronidase
• Trypsin

Topics

• Animals
• Connective Tissue (drug effects, injuries, physiology, ultrastructure)
• Granulation Tissue (drug effects, physiology, ultrastructure)
• Hexosaminidases (pharmacology)
• Male
• Microscopy, Electron, Scanning
• Rats
• Skin (drug effects, injuries, ultrastructure)
• Skin Physiological Phenomena
• Stimulation, Chemical
• Time Factors
• Trypsin (pharmacology)
• Wound Healing (drug effects, physiology)