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Poly ICLC enhances the antimalarial activity of chloroquine against multidrug-resistant Plasmodium yoelii nigeriensis in mice.

Abstract
Swiss mice infected with multidrug-resistant Plasmodium yoelii nigeriensis were treated with polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethyl cellulose (Poly ICLC), a potent interferon (IFN) inducer and immune enhancer, in combination with chloroquine (CQ), which completely eliminated the malaria parasite from these animals. The enhancement of the antimalarial activity of poly ICLC was found to be completely reversed by the cytochrome P-450 inducer, phenobarbitone. No effect of Nw nitro-L-arginine (NLA), an inhibitor of nitric oxide, was seen on the enhancement of the antimalarial activity of CQ by Poly ICLC. These results suggest the possible involvement of cytochrome P-450 enzyme-mediated mechanism in the enhancement of the antimalarial activity of CQ by Poly ICLC.
AuthorsA Awasthi, S Mehrotra, V Bhakuni, G P Dutta, H B Levy, R K Maheshwari
JournalJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research (J Interferon Cytokine Res) Vol. 17 Issue 7 Pg. 419-23 (Jul 1997) ISSN: 1079-9907 [Print] United States
PMID9243375 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Antimalarials
  • Interferon Inducers
  • Polylysine
  • poly ICLC
  • Chloroquine
  • Cytochrome P-450 Enzyme System
  • Carboxymethylcellulose Sodium
  • Poly I-C
  • Phenobarbital
Topics
  • Animals
  • Antimalarials (therapeutic use)
  • Carboxymethylcellulose Sodium (analogs & derivatives, therapeutic use)
  • Chloroquine (therapeutic use)
  • Cytochrome P-450 Enzyme System (biosynthesis)
  • Drug Resistance, Multiple
  • Drug Therapy, Combination
  • Enzyme Induction
  • Interferon Inducers (therapeutic use)
  • Mice
  • Phenobarbital (therapeutic use)
  • Plasmodium yoelii (drug effects)
  • Poly I-C (therapeutic use)
  • Polylysine (analogs & derivatives, therapeutic use)

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