FK143 (4-[3-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]-1H-indol-1-yl] -
butyric acid) is a new non-steroidal inhibitor of
steroid 5 alpha-reductase (5 alpha-reductase). The effects of
FK143 on prostate size and histopathology of mature male beagle dogs were investigated and compared with those of
finasteride (a steroidal
5 alpha-reductase inhibitor), and
allylestrenol and
chlormadinone acetate (CMA) (
androgen receptor antagonists).
FK143 was orally administered to the dogs daily for 12 weeks. At doses of 10 and 32 mg/kg,
FK143 significantly reduced prostate volume to about 60% of the initial value, and dogs treated with
FK143 showed a dose-dependent glandular epithelial
atrophy in the prostate.
FK143 showed no abnormal changes in organ weights and histopathology of the adrenal, testis, pituitary and liver. The degree of prostate reduction in the dogs treated with
FK143 (10 and 32 mg/kg) was almost the same as that by
finasteride (1.0 mg/kg) and smaller than that by
allylestrenol (10 mg/kg) or CMA (10 mg/kg). However,
allylestrenol increased liver weights, and CMA increased liver and reduced adrenal weights. These results demonstrate that
FK143 can decrease the volume of the dog prostate without any influence on other organs, and they suggest that
FK143 is a good candidate for the treatment for
benign prostatic hyperplasia.