Inactivated poliovirus vaccine alone or sequential inactivated and oral poliovirus vaccine in two-, four- and six-month-old infants with combination Haemophilus influenzae type b/hepatitis B vaccine.

Abstract

BACKGROUND:

Advisory committees have recommended the increased use of inactivated poliovirus vaccine (IPV) for children.

OBJECTIVES:

The purpose of this study was to assess the safety and immunogenicity of three schedules using IPV administered with diphtheria and tetanus toxoids and whole cell pertussis vaccines in a dual-chambered syringe. Children also received a combination of Haemophilus influenzae type b (Hib) and hepatitis B vaccines (COMVAX).

METHODS:

All infants (n = 295) received IPV and COMVAX at 2 and 4 months of age and IPV, oral poliovirus vaccine (OPV) or both vaccines at 6 months and OPV at 15 months of age.

RESULTS:

After two doses of IPV 96 to 100% of infants had antibodies to poliomyelitis viruses types 1, 2 and 3, and after a third dose of vaccine (IPV or OPV) all but one child had antibodies to all three poliovirus types. After two doses of COMVAX 89 and 96% of children had protective levels of antibody to Hib and hepatitis B, respectively.

CONCLUSIONS:

IPV is highly immunogenic in a two-dose schedule. Administration of a third dose of IPV or a dose of OPV at 6 months of age is highly effective. Simultaneous administration of a combination H. influenzae type b/hepatitis B vaccine did not interfere with the response to IPV.

• Authors: N A Halsey, M Blatter, G Bader, M L Thoms, F F Willingham, J C O'Donovan, L Pakula, F Berut, K S Reisinger, C Meschievitz
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 16 Issue 7 Pg. 675-9 (Jul 1997) ISSN: 0891-3668 [Print] United States
• PMID: 9239772 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Haemophilus Vaccines
• Haemophilus influenzae type b polysaccharide vaccine
• Hepatitis B Vaccines
• Poliovirus Vaccine, Inactivated
• Polysaccharides, Bacterial
• Vaccines, Inactivated

Topics

• Bacterial Capsules
• Female
• Haemophilus Vaccines (administration & dosage, adverse effects, immunology)
• Hepatitis B Vaccines (administration & dosage, adverse effects, immunology)
• Humans
• Infant
• Male
• Poliovirus Vaccine, Inactivated (administration & dosage, adverse effects, immunology)
• Polysaccharides, Bacterial (administration & dosage, adverse effects, immunology)
• Vaccines, Inactivated (administration & dosage, adverse effects, immunology)