Hyperamylasemia due to macroamylasemia in adult gluten enteropathy.

Abstract

We report hyperamylasemia due to macroamylasemia in a 33-year-old-woman with gluten enteropathy. Macroamylasemia was demonstrated by precipitation of 97% of amylase activity with PEG 6000. It was associated with increased serum IgA, with elevated values of specific IgA antibodies against alpha-gliadin and with a high titre of IgA anti-endomysium antibodies. Macroamylasemia disappeared after 2 months of a strict gluten-free diet. These data suggest that the increased IgA concentration in adult gluten enteropathy led to increased macroamylase formation.

• Authors: G Bonetti, G Serricchio, A Giudici, M Bettonagli, G B Vadacca, R Bruno, E Coslovich, R Moratti
• Journal: Scandinavian journal of clinical and laboratory investigation (Scand J Clin Lab Invest) Vol. 57 Issue 3 Pg. 271-3 (May 1997) ISSN: 0036-5513 [Print] England
• PMID: 9238763 (Publication Type: Case Reports, Journal Article)

Chemical References

• Macromolecular Substances
• Gliadin
• Amylases
• macroamylase

Topics

• Adult
• Amylases (blood, urine)
• Celiac Disease (blood, enzymology, immunology)
• Female
• Gliadin (immunology)
• Humans
• Macromolecular Substances