[Mechanisms of release of adrenaline and noradrenaline from the caudal mesenteric ganglion of dogs].

Abstract

Adrenaline (A) and noradrenaline (N) release from the caudal mesenteric ganglion (CMG) during preganglionic nerve stimulation is due to acetylcholine action on N--and M-cholinoreceptors of ganglion's adrenergic structures (GAS) and probably, primarily on SIF--cells, whereas during peripheral reflexes of CMG it is related to the excitation of noncholinergic afferent neurons which affect the corresponding receptors of GAS. A and N release is inhibited via M-receptors. There is a complex relationship between receptor fields of GAS. Hemicholinium as well as N--cholinoblocking agents, during first minutes of their application to the ganglion elicit A and N release both before and after preganglionic fiber degeneration, which indicates their postsynaptic effect on the cholinoreceptors. Changes in A and N in the ganglion during peripheral reflexes are increased after prolonged action of hemicholinium and chronic decentralisation of CMG.

• Authors: I A Bulygin, V M Reprintseva
• Journal: Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova (Fiziol Zh SSSR Im I M Sechenova) Vol. 63 Issue 10 Pg. 1438-45 (Oct 1977) ISSN: 0015-329X [Print] Russia (Federation)
• Vernacular Title: Mekhanizmy vydeleniia adrenalina i noradrenalina iz kaudal'nogo bryzheechnogo gangliia sobaki.
• PMID: 923849 (Publication Type: Journal Article)

Chemical References

• Receptors, Muscarinic
• Receptors, Nicotinic
• Hemicholinium 3
• Neostigmine
• Acetylcholine
• Norepinephrine
• Epinephrine

Topics

• Acetylcholine (pharmacology)
• Animals
• Autonomic Fibers, Postganglionic (physiology)
• Autonomic Fibers, Preganglionic (physiology)
• Dogs
• Electric Stimulation
• Epinephrine (metabolism)
• Ganglia, Autonomic (metabolism)
• Hemicholinium 3 (pharmacology)
• Neostigmine (pharmacology)
• Norepinephrine (metabolism)
• Receptors, Muscarinic
• Receptors, Nicotinic