Biological activities of pseudomycin A, a lipodepsinonapeptide from Pseudomonas syringae MSU 16H.

Abstract

Similarly to other Pseudomonas lipodepsinonapeptides, pseudomycin A inhibits proton extrusion from maize roots, promotes closure of stomata in Vicia faba, necrosis of tobacco leaves, haemolysis of human erythrocytes, affects H(+)-ATPase activity and proton translocation in plasma membrane vesicles, and stimulates succinate respiration in pea mitochondria. In general, the biological activities of pseudomycin A are lower than those of syringomycin-E, the prototype member of this family of bacterial metabolities. This difference might depend on the diverse number and distribution of charged residues in the peptide moiety of these compounds.

• Authors: D Di Giorgio, L Camoni, C Marchiafava, A Ballio
• Journal: Phytochemistry (Phytochemistry) Vol. 45 Issue 7 Pg. 1385-91 (Aug 1997) ISSN: 0031-9422 [Print] England
• PMID: 9237401 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bacterial Proteins
• Peptides, Cyclic
• pseudomycin A
• Proton-Translocating ATPases

Topics

• Amino Acid Sequence
• Bacterial Proteins (pharmacology, toxicity)
• Cell Membrane (drug effects, enzymology)
• Erythrocytes (drug effects)
• Hemolysis
• Humans
• Mitochondria (drug effects, physiology)
• Peas (drug effects, physiology)
• Peptides, Cyclic (pharmacology, toxicity)
• Plant Leaves (drug effects, metabolism)
• Plant Roots (drug effects, metabolism)
• Plants (drug effects)
• Plants, Toxic
• Proton-Translocating ATPases (metabolism)
• Pseudomonas (chemistry)
• Tobacco (drug effects, metabolism)
• Zea mays (drug effects, metabolism)