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Zinc-bis-histidinate preserves cardiac function in a porcine model of cardioplegic arrest.

AbstractBACKGROUND:
We examined the ability of zinc-bis-histidinate to preserve postarrest myocardial function when added to a standard crystalloid cardioplegic solution.
METHODS:
Domestic pigs (35 to 50 kg) on left-sided cardiopulmonary bypass were subjected to 90 minutes of regional ischemia followed by 60 minutes of hypothermic cardioplegic arrest induced by antegrade infusion of 20 mL/kg cold St. Thomas' #2 cardioplegic solution with or without 100 mumol/L of zinc-bis-histidinate and maintained by infusion of 10 mL/kg of the same every 20 minutes. During reperfusion function was assessed at 1 and 3 hours over increasing preloads using the right-sided bypass method.
RESULTS:
At roller pump flows up to 2,000 mL/min, stroke work index-end-diastolic pressure curves were significantly (p < 0.05) higher and shifted to the left in treated hearts. In a series of pigs, echocardiography was used to determine end-diastolic and end-systolic volumes. At roller pump flows up to 3,500 mL/min, end-systolic pressure-end-systolic volume curves were significantly higher and shifted to the left in treated hearts. Left ventricular ejection fraction, fractional shortening, stroke volume, and cardiac output were significantly (p < 0.05) higher in treated hearts. Electron microscopy revealed that mitochondria in tissue not at risk appeared more swollen in control hearts.
CONCLUSIONS:
The results of this study support the conclusion that zinc-bis-histidinate is effective as a myocardial preservative when added to a crystalloid cardioplegic solution.
AuthorsS R Powell, R L Nelson, J Finnerty, D Alexander, G Pottanat, K Kooker, R J Schiff, J Moyse, S Teichberg, A J Tortolani
JournalThe Annals of thoracic surgery (Ann Thorac Surg) Vol. 64 Issue 1 Pg. 73-80 (Jul 1997) ISSN: 0003-4975 [Print] UNITED STATES
PMID9236338 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Cardioplegic Solutions
  • Organometallic Compounds
  • zinc bis(histidinate)
  • Histidine
  • Zinc
Topics
  • Animals
  • Blood Pressure (drug effects)
  • Cardioplegic Solutions (pharmacology)
  • Disease Models, Animal
  • Heart (drug effects)
  • Heart Arrest, Induced
  • Histidine (analogs & derivatives, pharmacology)
  • Myocardial Contraction
  • Organometallic Compounds (pharmacology)
  • Swine
  • Ventricular Function, Left (drug effects)
  • Zinc (pharmacology)

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