Immunohistochemical demonstration of bone morphogenetic protein in odontogenic tumors.

Abstract

The aim of the present study was to describe the expression and distribution of bone morphogenetic protein (BMP) in odontogenic tumors by immunohistochemistry using monoclonal antibody against bovine BMP (BMPMcAb). Eight types of odontogenic tumors (44 cases), including ameloblastoma (20 cases), cementifying fibroma (8 cases), benign cementoblastoma (5 cases), dentinoma (3 cases), compound odontoma (2 cases), adenomatoid odontogenic tumor (2 cases), calcifying epithelial odontogenic tumor (2 cases) and odontogenic fibroma (2 cases), were studied. The results showed that, according to the immunostaining pattern of BMPMcAb, tumors could be classified into two types: all cementifying fibromas, benign cementoblastomas, dentinomas, odontogenic fibromas, and compound odontomas demonstrated a positive reaction, whereas all ameloblastomas, adenomatoid odontogenic tumors, and calcifying epithelial odontogenic tumors were negative. BMPMcAb-positive odontogenic tumors were those tumors with formation of enamel, dentin, cementum or bone. Therefore, BMP might play an important role in the formation of calcified dental tissues and the development of odontogenic tumors contaning such tissues.

• Authors: Y H Gao, L J Yang, A Yamaguchi
• Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 26 Issue 6 Pg. 273-7 (Jul 1997) ISSN: 0904-2512 [Print] Denmark
• PMID: 9234187 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal
• Bone Morphogenetic Proteins
• Coloring Agents

Topics

• Ameloblastoma (pathology)
• Ameloblasts (cytology)
• Animals
• Antibodies, Monoclonal
• Bone Morphogenetic Proteins (analysis, genetics)
• Bone and Bones (pathology)
• Cattle
• Coloring Agents
• Cytoplasm (ultrastructure)
• Dental Cementum (pathology)
• Dental Enamel (pathology)
• Dentin (pathology)
• Epithelial Cells
• Gene Expression Regulation, Neoplastic
• Humans
• Immunoenzyme Techniques
• Immunohistochemistry
• Odontoblasts (cytology)
• Odontogenic Tumors (pathology)
• Odontoma (pathology)
• Tooth Germ (cytology)