Use of polyetherurethane to improve the biocompatibility of vascular stents.

Abstract

PURPOSE:

To investigate potential differential growth on neointima following overdilating arterial trauma with polyetherurethane-coated versus bare metallic stents in swine.

METHODS:

Twelve specially constructed tantalum stents, 6 coated with polyetherurethane block copolymer and 6 uncoated, were overdilated by 25% in 12 normal renal arteries of six swine. The stents were harvested 8 weeks after implantation and prepared for histologic examination. Neointimal thickness was quantified and analyzed for significant differences between coated and uncoated prostheses.

RESULTS:

All specimens demonstrated fractures of the internal elastic lamina consistent with vascular injury. There was significantly less neointimal formation (0.0001 < p < 0.05) in coated specimens as compared to uncoated controls in each test animal.

CONCLUSIONS:

The vascular response to overdilating stent trauma appears to be moderated with the use of polyetherurethane block copolymer as compared to control.

• Authors: A B Fontaine, S Dos Passos, D Spigos, J Cearlock, A Urbaneja
• Journal: Journal of endovascular surgery : the official journal of the International Society for Endovascular Surgery (J Endovasc Surg) Vol. 2 Issue 3 Pg. 255-65 (Aug 1995) ISSN: 1074-6218 [Print] United States
• PMID: 9234140 (Publication Type: Journal Article)

Chemical References

• Biocompatible Materials
• Tantalum
• Polytetrafluoroethylene

Topics

• Animals
• Biocompatible Materials
• Equipment Design
• Hyperplasia
• Polytetrafluoroethylene
• Renal Artery (pathology)
• Stents
• Swine
• Tantalum
• Tunica Intima (pathology)