d-Limonene inhibits N-nitrosobis(2-oxopropyl)amine induced hamster pancreatic carcinogenesis.

Abstract

The effect of d-limonene on pancreatic carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine (BOP) was investigated in Syrian golden hamsters. During and after 5 weekly injections of BOP, each hamster was fed diet containing d-limonene. In week 26, quantitative histological analysis showed that prolonged treatment with d-limonene significantly reduced the number of pancreatic carcinomas. Administration of d-limonene did not cause a significant increase in the apoptotic index, but caused a significant decrease in the BrdU labeling index of carcinoma. These findings indicate that d-limonene inhibits the development of pancreatic carcinoma not by enhancing tumor cell loss through apoptosis, but rather by inhibiting cell proliferation.

• Authors: A Nakaizumi, M Baba, H Uehara, H Iishi, M Tatsuta
• Journal: Cancer letters (Cancer Lett) Vol. 117 Issue 1 Pg. 99-103 (Jul 15 1997) ISSN: 0304-3835 [Print] Ireland
• PMID: 9233838 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cyclohexenes
• Nitrosamines
• Terpenes
• nitrosobis(2-oxopropyl)amine
• Limonene
• Bromodeoxyuridine

Topics

• Animals
• Apoptosis (drug effects)
• Body Weight (drug effects)
• Bromodeoxyuridine (metabolism)
• Carcinoma (chemically induced, pathology)
• Cricetinae
• Cyclohexenes
• DNA Replication (drug effects)
• Limonene
• Male
• Mesocricetus
• Nitrosamines (pharmacology)
• Pancreatic Neoplasms (chemically induced, pathology)
• Terpenes (pharmacology)