Pulvinatal, a novel bioactive metabolite from the basidiomycete Nidularia pulvinata (Schw.) Fr.

Abstract

Pulvinatal (1) was isolated from fermentations of Nidularia pulvinata as an inducer of differentiation of HL-60 promyelocytic leukemia cells. Its structure was elucidated by spectroscopic methods. In addition, N. pulvinata was found to produce 2,4,5-trihydroxy-6-methyl-benzenecarbaldehyde (2) and orsellinic acid (3). Pulvinatal exhibits weak antifungal and only marginal cytotoxic activities.

• Authors: U Becker, G Erkel, G Kocksch, T Anke, O Sterner
• Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences (Z Naturforsch C J Biosci) 1997 May-Jun Vol. 52 Issue 5-6 Pg. 313-8 ISSN: 0939-5075 [Print] Germany
• PMID: 9232889 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Antineoplastic Agents, Phytogenic
• Pyrans
• pulvinatal

Topics

• Antifungal Agents (chemistry, isolation & purification, toxicity)
• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, toxicity)
• Basidiomycota
• Cell Differentiation (drug effects)
• Fermentation
• Fungi (drug effects)
• HL-60 Cells (cytology, drug effects)
• Humans
• Microbial Sensitivity Tests
• Molecular Structure
• Pyrans (chemistry, isolation & purification, toxicity)
• Tumor Cells, Cultured