Abstract | STUDY DESIGN: OBJECTIVES: SUMMARY OF BACKGROUND DATA: No previous study has assessed the chemonucleolysis with chondroitinase ABC in the displaced discs. The changes of intervertebral disc syndrome were evaluated in this study. METHODS: RESULTS: Forty-eight dogs were evaluated for the efficacy of the chemonucleolytic treatment with chondroitinase ABC. At 1 week after injection, 45 of 48 dogs showed some improvement in symptoms and signs. No adverse reactions were observed. There was no recurrence of symptoms in nine dogs who were observed from 14 months to 3 years after injection. CONCLUSION:
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Authors | T Takahashi, M Nakayama, S Chimura, K Nakahara, M Morozumi, K Horie, Y Fujita, T Hirose |
Journal | Spine
(Spine (Phila Pa 1976))
Vol. 22
Issue 13
Pg. 1435-9; discussion 1446-7
(Jul 01 1997)
ISSN: 0362-2436 [Print] United States |
PMID | 9231960
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Cervical Vertebrae
(drug effects, pathology)
- Chondroitin Lyases
(therapeutic use)
- Dog Diseases
(drug therapy, pathology)
- Dogs
- Female
- Injections, Intralesional
(veterinary)
- Intervertebral Disc Chemolysis
(veterinary)
- Intervertebral Disc Displacement
(drug therapy, pathology, veterinary)
- Lumbar Vertebrae
(drug effects, pathology)
- Male
- Spinal Diseases
(drug therapy, pathology)
- Thoracic Vertebrae
(drug effects, pathology)
- Treatment Outcome
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