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[Chromatin-protective action of the biologically active preparation BTK-8L in tetrachloromethane and chlorophos poisoning].

Abstract
Results obtained from the study of the interaction between the phytosteroid preparation (BTK-8L) and fractionated rat liver nuclear chromatin under conditions of the tetrachloromethane and chlorophos intoxications are described. It is shown that preventive injection of BTK-8L to the animals has a partial protective effect on transcriptionally active and repressed liver chromatin. This preparation interacts with chromatin histone proteins binding with them and changes the nucleoprotein complex structure as a results of which the chromatin fraction components become less accessible to the damaging action of tetrachloromethane and chlorophos. The BTK-8L protective effect is exhibited on the DNA replication and transcriptional levels under conditions of tetrachloromethane and chlorophos intoxications.
AuthorsE L Levitskiĭ, Iu I Gubskiĭ, R G Primak, A G Goriushko, Iu D Kholodova, I E Vistunova, A N Marchenko
JournalUkrainskii biokhimicheskii zhurnal (1978) (Ukr Biokhim Zh (1978)) 1996 Sep-Oct Vol. 68 Issue 5 Pg. 76-84 ISSN: 0201-8470 [Print] Ukraine
Vernacular TitleZashchitnoe po otnosheniiu k khromatinu deĭstvie biologicheski aktivnogo kompleksa BTK-8L v usloviiakh intoksikatsii tetrakhlormetanom i khlorofosom.
PMID9229857 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antioxidants
  • BTK 8L preparation
  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • Fluorescent Dyes
  • Histones
  • Steroids
  • DNA
  • Trichlorfon
  • Ethidium
Topics
  • Animals
  • Antioxidants (therapeutic use)
  • Carbon Tetrachloride Poisoning (drug therapy)
  • Chromatin (drug effects)
  • Chromosomal Proteins, Non-Histone (drug effects)
  • DNA (drug effects)
  • Ethidium
  • Fluorescent Dyes
  • Histones (drug effects)
  • Male
  • Rats
  • Rats, Wistar
  • Steroids (therapeutic use)
  • Transcription, Genetic (drug effects)
  • Trichlorfon (poisoning)

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